IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.

@article{Nograles2009IL22producingT,
  title={IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.},
  author={K. Nograles and Lisa C. Zaba and A. Shemer and J. Fuentes-Duculan and I. Cardinale and T. Kikuchi and M. Ramon and R. Bergman and J. Krueger and E. Guttman-Yassky},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 6},
  pages={
          1244-52.e2
        }
}
BACKGROUND Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear. OBJECTIVE To examine differences in IL-23/TH17 signal between these diseases and establish relative frequencies of T-cell subsets in AD. METHODS Skin biopsies and peripheral blood were collected from… Expand
CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22.
TLDR
It is demonstrated that CD8(+) T cells are a significant and previously unappreciated source of inflammatory cytokine production in both AD and psoriasis. Expand
Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis
TLDR
The increased presence of Tc17 and Tc22 cells in lesional psoriatic skin suggests that these types of CD8 T cells play a significant role in the pathogenesis of psoriasis and demonstrates plasticity in their cytokine production profile. Expand
Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population.
TLDR
Severe AD is accompanied by expansion of skin-homing TH2/TC2 and TH22/TC22 subsets with lower TH1/TC1 frequencies, which create a critical basis for studying alterations in immune activation in adults and pediatric patients with AD. Expand
CD4+ T cell depletion changes the cytokine environment from a TH1/TH2 response to a TC17-like response in a murine model of atopic dermatitis.
TLDR
It is shown that NC/Nga mice develop AD-like disease following CD4 depletion, mirrored by an increased production of IL-17A, which it is suggested are produced by T(C)17 cells, the cytotoxic T cell counterpart to T(H) 17 cells. Expand
IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma
TLDR
Results suggest that IL-22 is important in establishing the tumor microenvironment for CTCL, and enhanced expression of CCL20 may explain epidermal hyperplasia and migration of CCR6+ cells, such as Langerhans cells, into lesional skin. Expand
The role of cytokines/chemokines in the pathogenesis of atopic dermatitis.
TLDR
Fine-tuning of the delicate 4-way balance among Th1, Th2, Th17/22 and T(reg) cells is required for the control of AD. Expand
Cytokines and T cells in atopic dermatitis.
TLDR
The new insight into the pathogenesis of AD is analysed, with special attention to those cytokines produced by the different T cell subpopulations, including IL-22-producing T-cells, which seem to correlate with the severity of the AD. Expand
CsA inhibits IL-22 production by memory CD4+ T cells from patients with psoriasis
TLDR
It is observed that CsA inhibits the production of IL-22 by CD4+ T cells from healthy donors in a dose-dependent manner, and that it inhibits IL- 22, IFN-γ and IL-17 production by CD 4+ T cells in psoriasis. Expand
The Role of Th17-Related Cytokines in Atopic Dermatitis
  • M. Sugaya
  • Medicine
  • International journal of molecular sciences
  • 2020
TLDR
Failure of clinical trials for investigating the efficacy of anti-IL-12/23 p40 in AD has suggested that IL-17 expressed in skin lesions should not be the main player but a bystander responding to barrier dysfunction. Expand
Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production
TLDR
The ability of cutaneous resident dendritic cells (DCs) to differentiate IL-22-producing cells is investigated and indicates that cutaneous DCs, especially LCs, may control the generation of distinct IL- 22 producing Th22 cells infiltrating into the skin. Expand
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