IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.

@article{Ma2008IL22IR,
  title={IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.},
  author={H. Ma and Spencer Liang and Jing Li and Lee Napierata and Tom Brown and Stephen Benoit and Mayra Senices and Davinder Gill and Kyriaki Dunussi-Joannopoulos and Mary I. Collins and Cheryl L. Nickerson-Nutter and Lynette A. Fouser and Deborah A. Young},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 2},
  pages={597-607}
}
Psoriasis is a chronic skin disease resulting from the dysregulated interplay between keratinocytes and infiltrating immune cells. We report on a psoriasis-like disease model, which is induced by the transfer of CD4(+)CD45RB(hi)CD25(-) cells to pathogen-free scid/scid mice. Psoriasis-like lesions had elevated levels of antimicrobial peptide and proinflammatory cytokine mRNA. Also, similar to psoriasis, disease progression in this model was dependent on the p40 common to IL-12 and IL-23. To… CONTINUE READING
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Naturally arising Foxp 3 - expressing CD 25 + CD 4 + regulatory T cells in self - tolerance and autoimmune disease

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