IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade.


OBJECTIVE Interleukin 22 (IL-22), a relatively new cytokine has been found to induce significant proliferation of human keratinocytes and fibroblast like synoviocytes (FLS) and thus plays an important role in the pathogenesis of autoimmune diseases like psoriasis and rheumatoid arthritis (RA) which are characterized by hyperproliferation of keratinocytes… (More)
DOI: 10.1016/j.cyto.2012.06.316