IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.

Abstract

IL-17-producing CD4+ T cells (Th17 cells) have well-described pathogenic roles in tissue inflammation and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE); however, the involvement of IL-21 in these processes has remained controversial. While IL-21 is an essential autocrine amplification factor for differentiation of Th17 cells… (More)
DOI: 10.1172/JCI75933

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