IL-21 signaling is critical for the development of type I diabetes in the NOD mouse.

@article{Spolski2008IL21SI,
  title={IL-21 signaling is critical for the development of type I diabetes in the NOD mouse.},
  author={Rosanne Spolski and Mohit V Kashyap and Constance Robinson and Zuxi Yu and Warren J Leonard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 37},
  pages={14028-33}
}
IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor gamma chain and plays important roles for normal Ig production, terminal B cell differentiation to plasma cells, and Th17 differentiation. IL-21 is elevated in several autoimmune diseases, and blocking its action has attenuated disease in MRL/lpr mice and in collagen-induced arthritis. The diabetes-associated Idd3 locus is at the Il2/Il21 locus, and elevated IL-21 was observed in the nonobese diabetic (NOD) mouse… CONTINUE READING
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