IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population.

@article{Barjon2017IL21PT,
  title={IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population.},
  author={Cl{\'e}ment Barjon and H A Michaud and Angeline Fages and C{\'e}cile D{\'e}jou and Alexandre Zampieri and Laetitia They and Aur{\'e}lie Gennetier and Françoise Sanchez and Laurent Gros and Jean-François Eliaou and Nathalie Bonnefoy and Virginie Lafont},
  journal={Oncoimmunology},
  year={2017},
  volume={7 1},
  pages={
          e1379642
        }
}
Vγ9Vδ2 T cells contribute to the immune response against many tumor types through their direct cytotoxic activity and capacity to regulate the biological functions of other immune cells, such as dendritic cells and IFN-γ-producing CD8+ T cells. However, their presence in the tumor microenvironment has also been associated with poor prognosis in breast, colon and pancreatic cancers. Additionally, recent studies demonstrated that cytokines can confer some plasticity to Vγ9Vδ2 T cells and promote… CONTINUE READING
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