IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.

@article{Wei2007IL21IP,
  title={IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.},
  author={Lai Wei and Arian D J Laurence and Kevin M. Elias and John J O'Shea},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={34605-10}
}
CD4(+) helper T cells can differentiate into several possible fates including: Th1, Th2, T regulatory, and Th17 cells. Although, cytokine production by non-T cells is an important factor in helper T cell differentiation, a characteristic feature of both Th1 and Th2 lineages is their ability to secrete cytokines that promote their respective differentiation. However, cytokines produced by T cells that help to sustain Th17 cells have not yet been identified. Here we show that IL-21 is a product… CONTINUE READING
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