IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.

@article{Fabrizi2014IL21IA,
  title={IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity.},
  author={Marta Fabrizi and Valentina Marchetti and Maria Mavilio and Arianna Marino and Viviana Casagrande and Michele Cavalera and Jos{\'e} Mar{\'i}a Moreno-Navarrete and Teresa Mezza and Gian Pio Sorice and Loredana Fiorentino and Rossella Menghini and Renato Lauro and Giovanni Monteleone and Andrea Giaccari and Jos{\'e} Manuel Fern{\'a}ndez Real and Massimo Federici},
  journal={Diabetes},
  year={2014},
  volume={63 6},
  pages={2086-96}
}
Obesity elicits immune cell infiltration of adipose tissue provoking chronic low-grade inflammation. Regulatory T cells (Tregs) are specifically reduced in adipose tissue of obese animals. Since interleukin (IL)-21 plays an important role in inducing and maintaining immune-mediated chronic inflammatory processes and negatively regulates Treg differentiation/activity, we hypothesized that it could play a role in obesity-induced insulin resistance. We found IL-21 and IL-21R mRNA expression… CONTINUE READING