IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

  title={IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.},
  author={Kesley Attridge and Chun Jing Wang and Lukasz Wardzinski and Rupert Kenefeck and Jayne L. Chamberlain and Claire N. Manzotti and Manfred Kopf and Lucy S. K. Walker},
  volume={119 20},
Modulation of regulatory T cell (Treg) suppression has important implications for vaccine development, the effectiveness of tumor surveillance, and the emergence of autoimmunity. We have previously shown that the cytokine IL-21 can counteract Treg suppression. However, whether this reflects an effect of IL-21 on Treg, conventional T cells, or antigen-presenting cells is not known. Here we have used lymphocyte populations from IL-21R-deficient mice to pinpoint which cell type needs to be… CONTINUE READING


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