IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.

@article{Hodge2012IL21IT,
  title={IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.},
  author={Lucy S. Hodge and Steve C Ziesmer and Zhi Zhang Yang and Frank J. Secreto and Morie A Gertz and Anne J. Novak and Stephen M Ansell},
  journal={Blood},
  year={2012},
  volume={120 18},
  pages={3774-82}
}
Cytokines within the tumor microenvironment play an important role in supporting the growth and survival of B-cell malignancies. One such cytokine, IL-21, promotes the growth of myeloma and Hodgkin lymphoma cells while inducing apoptosis in chronic lymphocytic leukemia. However, the biologic significance of IL-21 has not been examined in Waldenstrom macroglobulinemia (WM), a B-cell lymphoma characterized by elevated serum IgM and a lymphoplasmacytic bone marrow infiltrate. We report here on the… CONTINUE READING
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