IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells.

@article{Vogelzang2014IL21CT,
  title={IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells.},
  author={Alexis Vogelzang and Helen M McGuire and Sue Min Liu and Brian S. Gloss and Karessa Mercado and Peter G. Earls and Marcel E. Dinger and Marcel L Batten and Jonathan Sprent and C Christopher King},
  journal={Journal of immunology},
  year={2014},
  volume={192 4},
  pages={1404-14}
}
The cytokine IL-21 has been shown to influence immune responses through both costimulatory effects on effector T cells and opposing inhibitory effects on T regulatory cells (Tregs). To distinguish the effect of IL-21 on the immune system from that of its effect on Tregs, we analyzed the role of IL-21/IL-21R signaling in mice made genetically deficient in IL-2, which exhibit a deficit in IL-2-dependent Foxp3 regulatory T cells and suffer from a fatal multiorgan inflammatory disease. Our findings… CONTINUE READING