IL-21 as new therapy for CLL?

  title={IL-21 as new therapy for CLL?},
  author={J. P. Kolb},
  volume={111 9},
CD40 receptor is a member of the TNF receptor family with a prominent role in the regulation of adaptive immune response. The receptor’s stimulation by specific CD40 ligand (CD40L) results in activation of macrophages, B cells, and dendritic cells. Vascular cells also express CD40, and stimulation by CD40L mediates inflammatory responses in the vascular wall. The 2 major signaling mediators downstream of CD40 are TRAF2 and TRAF6. Whereas TRAF2 function seems to be confined to the signaling of… CONTINUE READING