IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques

@article{Ortiz2016IL21AP,
  title={IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques},
  author={Alexandra M Ortiz and Zachary A Klase and Sarah R DiNapoli and Ivan Vujkovic-Cvijin and K Carmack and Molly R. Perkins and Nina A Calantone and Carol L. Vinton and Nadeene E. Riddick and Jennifer Gallagher and Nichole R. Klatt and Joseph M McCune and Jacob D Estes and Mirko Paiardini and Jason M. Brenchley},
  journal={Mucosal Immunology},
  year={2016},
  volume={9},
  pages={458-467}
}
Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been attributed to persistent immune dysfunction, in part due to abnormalities at the gastrointestinal barrier. In particular, the poor reconstitution of gastrointestinal Th17 cells correlates with residual translocation of dysbiotic, immunostimulatory microflora across a compromised intestinal epithelial barrier. We have previously demonstrated that oral probiotics promote increased intestinal CD4+ T-cell… CONTINUE READING
Highly Cited
This paper has 40 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
21 Citations
48 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…