IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses.

@article{McGuire2015IL21AI,
  title={IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses.},
  author={Helen M McGuire and Alexis Vogelzang and Joanna Claire Warren and Claudia Loetsch and Karlo D. T. Natividad and Tyani D Chan and Robert Brink and Marcel L Batten and Cecile Carol-Ann King},
  journal={Journal of immunology},
  year={2015},
  volume={195 11},
  pages={
          5123-35
        }
}
The selection of affinity-matured Ab-producing B cells is supported by interactions with T follicular helper (Tfh) cells. In addition to cell surface-expressed molecules, cytokines produced by Tfh cells, such as IL-21 and IL-4, provide B cell helper signals. In this study, we analyze how the fitness of Th cells can influence Ab responses. To do this, we used a model in which IL-21R-sufficient (wild-type [WT]) and -deficient (Il21r(-/-)) Ag-specific Tfh cells were used to help immunodeficient… CONTINUE READING
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