IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

@article{Wang2016IL21IL21RSS,
  title={IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice},
  author={Y. Wang and Xuefeng Jiang and J. Zhu and Dan Yue and Xiaoqing Zhang and Xiao Wang and Yong You and Biao Wang and Ying Xu and Changlong Lu and Xun Sun and Y. Yoshikai},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD is not very clear. In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that IL-21R.KO mice were more… Expand
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