IL-2: the first effective immunotherapy for human cancer.


The ability of IL-2 to expand T cells with maintenance of functional activity has been translated into the first reproducible effective human cancer immunotherapies. The administration of IL-2 can lead to durable, complete, and apparently curative regressions in patients with metastatic melanoma and renal cancer. The growth of large numbers of tumor-infiltrating lymphocytes with in vitro anti-cancer activity in IL-2 has led to the development of cell transfer therapies that are highly effective in patients with melanoma. The genetic modification of T cells with genes encoding αβ TCRs or chimeric Ag receptors and the administration of these cells after expansion in IL-2 have extended effective cell transfer therapy to other cancer types.

DOI: 10.4049/jimmunol.1490019

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@article{Rosenberg2014IL2TF, title={IL-2: the first effective immunotherapy for human cancer.}, author={Steven Aaron Rosenberg}, journal={Journal of immunology}, year={2014}, volume={192 12}, pages={5451-8} }