IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor.

@article{Minami1995IL2SR,
  title={IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor.},
  author={Yasuhiro Minami and T. Taniguchi},
  journal={Current opinion in cell biology},
  year={1995},
  volume={7 2},
  pages={156-62}
}
Cytokine receptors transduce signals to the cell interior upon binding of their cognate ligands, eventually leading to cellular responses such as cellular proliferation, differentiation and other effector functions. Most of the cytokine receptors, including the interleukin (IL)-2 receptor, consist of two or more distinct subunits, yet none possess any known catalytic activity such as protein tyrosine kinase activity. Significant advances have recently been made in identifying the multiple… CONTINUE READING

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