IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients

@article{Roberti2012IL2OI,
  title={IL-2- or IL-15-activated NK cells enhance Cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients},
  author={Mar{\'i}a Paula Roberti and Yamila Sol Rocca and Mora Amat and Mar{\'i}a Betina Pampena and Jos{\'e} Loza and Federico Andr{\'e}s Col{\'o} and Ver{\'o}nica Fabiano and Carlos Mart{\'i}n Loza and Juan Mart{\'i}n Arriaga and Michele Bianchini and Mar{\'i}a Marcela Barrio and Alicia In{\'e}s Bravo and Enzo Domenichini and Reinaldo Chac{\'o}n and Jos{\'e} Mordoh and Estrella Mariel Levy},
  journal={Breast Cancer Research and Treatment},
  year={2012},
  volume={136},
  pages={659-671}
}
Triple-negative breast cancer (TNBC) patients do not benefit from target-specific treatments and is associated with a high relapse rate. Epidermal growth factor receptor is frequently expressed in TNBC and is a candidate for new therapies. In this work, we studied Cetuximab-mediated immune activity by NK cells. Thirteen activating/inhibitory receptors were examined on peripheral blood and tumor infiltrating NK cells. NK-cell functionality was evaluated using as effectors tumor-modulated NK… CONTINUE READING
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Rapid development of exhaustion and downregulation of eo- mesodermin limits the anti-tumor activity of adoptively trans- ferred murine natural killer cells

  • S Gill, AE Vasey, +8 authors RS Negrin
  • 2012
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