IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.


Interleukin (IL)-2 is a type I four-alpha-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor alpha chain (IL-7Ralpha) mRNA and protein. The fact that IL-7Ralpha is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor gamma chain, gamma(c), which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.

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@article{Xue2002IL2NR, title={IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.}, author={Hai-Hui Xue and Panu E . Kovanen and Cynthia A. Pise-Masison and Maria L. Berg and Michael F. Radovich and John N. Brady and Warren J Leonard}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2002}, volume={99 21}, pages={13759-64} }