IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.

@article{Heinzel1993IL2IN,
  title={IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.},
  author={Frederick P. Heinzel and Ronald M. Rerko and Farah Hatam and Richard M Locksley},
  journal={Journal of immunology},
  year={1993},
  volume={150 9},
  pages={3924-31}
}
BALB/c mice are highly susceptible to disseminated infection with the intracellular protozoa Leishmania major. Progression of disease requires in vivo expansion of Th2 CD4+ lymphocytes and is reversed by treatment with anti-IL-4 monoclonal antibody. Inasmuch as IL-2 may be necessary for both the production of IL-4 and differentiation of Th2 cells, the possible contribution of IL-2 to progressive infection was examined. Four weekly injections of anti-IL-2 mAb (S4B6) cured more than 80% of BALB/c… CONTINUE READING

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