IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.

@article{Huang2014IL2inducibleTC,
  title={IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.},
  author={Weishan Huang and Ah-Reum Jeong and Arun Kumar Kannan and Lu Huang and Avery August},
  journal={Journal of immunology},
  year={2014},
  volume={193 5},
  pages={2267-72}
}
IL-2-inducible T cell kinase (ITK) is a key signaling mediator downstream of TCR, mediating T cell positive selection, as well as innate T cell and CD4(+) Th2/Th17 differentiation. In this article, we show that ITK also negatively tunes IL-2-induced expansion of conventional Foxp3-expressing regulatory T cells (Tregs). In vivo, Treg abundance is inversely correlated with ITK expression, and inducible Treg development is inversely dependent on ITK kinase activity. While Treg development normally… CONTINUE READING
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