IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells.

@article{Brandenburg2008IL2II,
  title={IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells.},
  author={Susan Brandenburg and Takeshi Takahashi and Maurus de la Rosa and Marko Janke and Gabriele Karsten and Till Muzzulini and Zane Orinska and Silvia Bulfone-Paus and Alexander Scheffold},
  journal={European journal of immunology},
  year={2008},
  volume={38 6},
  pages={1643-53}
}
Interleukin-2 (IL-2) treatment is currently used to enhance T cell-mediated immune responses against tumors or in viral infections. At the same time, IL-2 is essential for the peripheral homeostasis of CD4(+)CD25(+)Foxp3(+ )regulatory T cells (Treg). In our study, we show that IL-2 is also an important activator of Treg suppressive activity in vivo. IL-2 treatment induces Treg expansion as well as IL-10 production and increases their suppressive potential in vitro. Importantly, in vivo… CONTINUE READING