IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb.

@article{Kamimura2006IL2IV,
  title={IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb.},
  author={Daisuke Kamimura and Yukihisa Sawa and Masae Sato and Eviryanti Agung and Toshio Hirano and Masaaki Murakami},
  journal={Journal of immunology},
  year={2006},
  volume={177 1},
  pages={306-14}
}
IL-2 is a potent immunostimulant and has been tested for clinical use, including in immunotherapy for cancers and HIV infection. Here we show that a widely used neutralizing anti-murine IL-2 mAb (S4B6) exhibits unexpected activities that enhance the treatment effects of IL-2 in vivo. Coinjection of the anti-IL-2 mAb with a plasmid carrying murine IL-2 cDNA significantly increased the serum IL-2 levels and induced a substantial increase in the division of CD8+ T and NK1.1(high) cells in vivo… CONTINUE READING

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