IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor.

@article{Jankovi1990IL2dependentPO,
  title={IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor.},
  author={Drina Lj Jankovi{\'c} and Angelita Rebollo and Anil Kumar and M A Gibert and Jacques Th{\'e}ze},
  journal={Journal of immunology},
  year={1990},
  volume={145 12},
  pages={4136-44}
}
An IL-4-dependent T cell clone (LD8) was isolated from the murine IL-2-dependent cytotoxic T cell line C30.1. This clone has lost the capacity to proliferate in response to IL-2 after long-term culture in IL-4. LD8 cells express the p70, but not the p55, subunit of the IL-2R on their cell surface. The number of p70 IL-2R molecules on LD8 cells is comparable with the number of high-affinity IL-2R on the parental C30.1 cell line. LD8 cells can efficiently internalize IL-2 through the p70 IL-2R… CONTINUE READING