IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).

@article{Splawski1990IL2DO,
  title={IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).},
  author={Judy B. Splawski and L M McAnally and Peter E Lipsky},
  journal={Journal of immunology},
  year={1990},
  volume={144 2},
  pages={562-9}
}
The effect of rIL-6 on the growth and differentiation of highly purified human peripheral blood B cells was examined. IL-6 alone induced minimal incorporation of [3H]thymidine by unstimulated or Staphylococcus aureus (SA)-stimulated B cells and did not augment proliferation induced by SA and IL-2. Similarly, IL-6 alone did not support the generation of Ig-secreting cells (ISC) or induce the secretion of Ig by unstimulated or SA-stimulated B cells. However, IL-6 did augment the generation of ISC… CONTINUE READING