IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways

@inproceedings{Xia2016IL2AT,
  title={IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways},
  author={Yang Xia and Huimin Tao and Yangyang Hu and Quanning Chen and Xin Chen and Leiming Xia and Li Zhou and Yi Wang and Yangyi Bao and Shiang Huang and Xiubao Ren and Steven K Lundy and Fu Qiang Dai and Qiao Li and Alfred T. C. Chang},
  booktitle={Oncotarget},
  year={2016}
}
We previously reported that antitumor B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10. In this study, we defined additional mechanisms involved in B cell antitumor immunity. Administration of IL-2 significantly augmented the therapeutic efficacy of adoptively transferred tumor-draining lymph node (TDLN) B cells which express IL- 2R. Culture supernatant of purified B splenocytes harvested from the mice that received adoptive transfer of 4T1 TDLN B cells plus… CONTINUE READING
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