IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.

@article{Wang2009IL2AI,
  title={IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.},
  author={Jinguo Wang and Linda S. Wicker and Pere Santamaria},
  journal={Seminars in immunology},
  year={2009},
  volume={21 6},
  pages={363-71}
}
Type 1 diabetes (T1D) is an organ-specific autoimmune disease featured by destruction of the insulin producing beta-cells of the pancreas by autoreactive T-lymphocytes. Putative environmental triggers conspire with a constellation of genetic elements scattered throughout the genome to elicit a multifactorial autoimmune response involving virtually every cell type of the immune system against pancreatic beta-cells. Recent highly powered genome-wide association studies have confirmed and… CONTINUE READING
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