IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.

@article{Kim2013IL2antiIL2CA,
  title={IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.},
  author={Myung-Gyu Kim and Tai Yeon Koo and J J Yan and Eunwon Lee and Kyu hyun Han and Jong Cheol Jeong and Han Ro and Beom Seok Kim and Sang Kyung Jo and Kook Hwan Oh and Charles D. Surh and Curie Ahn and Jaeseok Yang},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2013},
  volume={24 10},
  pages={1529-36}
}
Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion injury (IRI), but the isolation and ex vivo expansion of these cells for clinical application remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a mediator of Treg expansion, can attenuate renal IRI in mice. IL-2C administered before bilateral renal IRI induced Treg expansion in both spleen and kidney, improved renal function, and attenuated histologic renal injury and… CONTINUE READING
23 Citations
25 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…