IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

@article{Jackaman2014IL2CD40activatedMR,
  title={IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice},
  author={Connie Jackaman and Danielle E Dye and Delia Jane Nelson},
  journal={AGE},
  year={2014},
  volume={36},
  pages={1315-1328}
}
The role of macrophages and their interactions with T cells during aging is not well understood. We determined if activating elderly-derived macrophages could rescue age-related and tumor-induced T cell dysfunction. Healthy elderly (18–24 months) Balb/c contained significantly more splenic IL-10-secreting M2-macrophages and myeloid-derived suppressor cells than young (6–8 weeks) mice. Exposure to syngeneic mesothelioma or lung carcinoma-conditioned media polarized peritoneal macrophages into… CONTINUE READING
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