IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

  title={IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice},
  author={Connie Jackaman and Danielle E Dye and Delia Jane Nelson},
The role of macrophages and their interactions with T cells during aging is not well understood. We determined if activating elderly-derived macrophages could rescue age-related and tumor-induced T cell dysfunction. Healthy elderly (18–24 months) Balb/c contained significantly more splenic IL-10-secreting M2-macrophages and myeloid-derived suppressor cells than young (6–8 weeks) mice. Exposure to syngeneic mesothelioma or lung carcinoma-conditioned media polarized peritoneal macrophages into… CONTINUE READING
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Advanced age impairs macrophage polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2012
View 4 Excerpts
Highly Influenced

Effects of aging on T cell function.

Current opinion in immunology • 2009
View 4 Excerpts
Highly Influenced

Determination of lymphocyte division by flow cytometry.

Journal of immunological methods • 1994
View 4 Excerpts
Highly Influenced

Aging predisposes to acute inflammatory induced

MN Bouchlaka, GD Sckisel, +16 authors WJ Murphy

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