IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress.

@article{Elfervig2001IL1betaSI,
  title={IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress.},
  author={Michelle Elfervig and Joe T Minchew and Ernst Francke and Mari Tsuzaki and Albert Joseph Banes},
  journal={Journal of cellular biochemistry},
  year={2001},
  volume={82 2},
  pages={290-8}
}
Chronic inflammation and altered mechanical loading are implicated as contributors to intervertebral disc degeneration. Biomechanical and biochemical factors play a role in disc degeneration but have received limited study. Mechanically, intervertebral discs are sheared during bending or twisting of the trunk. Biochemically, IL-1beta, detected in degenerative discs, promotes metalloproteinase expression. We hypothesized that disc cells might respond to shear stress and IL-1beta in a calcium… CONTINUE READING

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