IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.

@article{Jung2003IL1betamediatedUO,
  title={IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.},
  author={Yun-jin Jung and Jennifer S. Isaacs and S Justin Lee and Jane B. Trepel and Leonard M. Neckers},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 14},
  pages={2115-7}
}
Growing evidence indicates that inflammation is a contributing factor leading to cancer development. However, pathways involved in this progression are not well understood. To examine whether HIF-1alpha is a factor linking inflammation and tumorigenesis, we investigated whether the HIF-1 signaling pathway was stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta) in A549 cells. We find that IL-1beta up-regulated HIF-1alpha protein under normoxia and activated the HIF-1… CONTINUE READING
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