IL-1beta-induced apoptosis in rat gastric enterochromaffin-like cells is mediated by iNOS, NF-kappaB, and Bax protein.

@article{Mahr2000IL1betainducedAI,
  title={IL-1beta-induced apoptosis in rat gastric enterochromaffin-like cells is mediated by iNOS, NF-kappaB, and Bax protein.},
  author={Sabine Mahr and Nina Neumayer and Markus Gerhard and Martin Classen and Christian Prinz},
  journal={Gastroenterology},
  year={2000},
  volume={118 3},
  pages={
          515-24
        }
}
BACKGROUND & AIMS Enterochromaffin-like (ECL) cells are histamine-containing endocrine cells in the gastric mucosa. Previous studies have shown that the proinflammatory cytokine interleukin (IL)-1beta present during chronic gastritis inhibits histamine synthesis in ECL cells and leads to sustained functional impairment. This study investigated the effects of IL-1beta on ECL cell apoptosis and the related signal-transduction mechanisms. METHODS ECL cells were isolated by pronase digestion and… CONTINUE READING

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