IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.

@article{Frank2010IL1RABE,
  title={IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.},
  author={Matthew G Frank and Ruth M Barrientos and Amy M. Hein and Joseph C Biedenkapp and Linda R. Watkins and Steven F. Maier},
  journal={Brain, behavior, and immunity},
  year={2010},
  volume={24 2},
  pages={254-62}
}
In normal aging, a peripheral immune challenge induces a sensitized and protracted neuroinflammatory response in parallel with long-term memory (LTM) impairments. Pro-inflammatory mediators of neuroinflammation impair LTM, synaptic plasticity and LTP. The immediate early gene Arc is considered a critical protein regulating LTM and synaptic plasticity. The present investigation examined whether (1) a peripheral Escherichia coli infection suppresses hippocampal Arc expression, and (2) central pro… CONTINUE READING
34 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…