IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis.

  title={IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis.},
  author={Ellen E. Witte and Georgios Kokolakis and Katrin Witte and S. B. Philipp and W D{\"o}cke and Nina Babel and Bianca Maria Wittig and Katarzyna Warszawska and Agata Kurek and Magdalena Erdmann-Keding and Stefanie Kunz and Khusru Asadullah and Marshall Edward Kadin and Hans Dieter Volk and Wolfram Sterry and Kerstin Wolk and Robert Sabat},
  journal={The Journal of investigative dermatology},
  volume={134 11},
Psoriasis is a common chronic inflammatory disease with characteristic skin alterations and functions as a model of immune-mediated disorders. Cytokines have a key role in psoriasis pathogenesis. Here, we demonstrated that out of 30 individually quantified cytokines, IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin. Cutaneous IL-19 overproduction was reflected by elevated IL-19 blood levels that correlated with psoriasis severity. Accordingly, anti… CONTINUE READING
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