IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.

@article{Schwarz2006IL18RU,
  title={IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.},
  author={Agatha Schwarz and Akira Maeda and Sonja St{\"a}nder and Harry van Steeg and Thomas P. Schwarz},
  journal={Journal of immunology},
  year={2006},
  volume={176 5},
  pages={
          2896-901
        }
}
UV-induced DNA damage has been recognized as the major molecular trigger for photoimmunosuppression. IL-12 prevents UV-induced immunosuppression via its recently discovered capacity to reduce DNA damage presumably via induction of DNA repair. Because IL-18 shares some biological activities with IL-12 we studied the effect of IL-18 on UV-induced DNA damage and immunosuppression. IL-18 reduced UV-induced apoptosis of keratinocytes and supported long-term cell survival on UV exposure. Injection of… CONTINUE READING
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