IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.

@article{BaniHani2009IL18NA,
  title={IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.},
  author={Ahmad H Bani-Hani and Jeffery A Leslie and Hiroshi Asanuma and Charles A Dinarello and Matthew T. Campbell and Daniel R. Meldrum and Honji Zhang and Karen L. Hile and Kirstan K Meldrum},
  journal={Kidney international},
  year={2009},
  volume={76 5},
  pages={500-11}
}
Ureteral obstruction results in renal fibrosis in part due to inflammatory injury. The role of interleukin-18 (IL-18), an important mediator of inflammation, in the genesis of renal fibrosis was studied using transgenic mice overexpressing human IL-18-binding protein. In addition, HK-2 cells were analyzed following direct exposure to IL-18 compared to control media. Two weeks after ureteral obstruction, the kidneys of wild-type mice had a significant increase in IL-18 production, collagen… CONTINUE READING

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