IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways.

@article{Yoo2005IL18IM,
  title={IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways.},
  author={Jae Kwang Yoo and Hyokjoon Kwon and Lee-Young Khil and Li Zhong Zhang and Hee-Sook Jun and J. W. Yoon},
  journal={Journal of immunology},
  year={2005},
  volume={175 12},
  pages={8280-6}
}
Macrophages are activated during an inflammatory response and produce multiple inflammatory cytokines. IL-18 is one of the most important innate cytokines produced from macrophages in the early stages of the inflammatory immune response. Monocyte chemoattractant protein (MCP-1) is expressed in many inflammatory diseases such as multiple sclerosis and rheumatoid arthritis, and its expression is correlated with the severity of the disease. Both IL-18 and MCP-1 have been shown to be involved in… CONTINUE READING

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