IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

@article{Doyle2014IL18AE,
  title={IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration},
  author={Sarah L Doyle and Ema Ozaki and Kiva Brennan and Marian M. Humphries and Kelly Mulfaul and James Keaney and Paul F. Mc Kenna and Arvydas Maminishkis and A S Kiang and Sean P Saunders and Emily Hams and Ed C Lavelle and Clair M Gardiner and Padraic G Fallon and Peter Adamson and Peter Humphries and Matthew Campbell},
  journal={Science Translational Medicine},
  year={2014},
  volume={6},
  pages={230ra44-230ra44}
}
Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to play a central role in the development of both “dry” and neovascular (“wet”) forms of the disease. We show that the inflammatory cytokine interleukin-18 (IL-18) can regulate choroidal neovascularization formation in mice. We observed that exogenous administration of mature… CONTINUE READING
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