IL-18–induced CD83+CCR7+ NK helper cells

  title={IL-18–induced CD83+CCR7+ NK helper cells},
  author={Robbie B. Mailliard and Sean M. Alber and Hongmei Shen and Simon C. Watkins and John Munn Kirkwood and Ronald B. Herberman and Pawel Kalinski},
  journal={The Journal of Experimental Medicine},
  pages={941 - 953}
In addition to their cytotoxic activities, natural killer (NK) cells can have immunoregulatory functions. We describe a distinct "helper" differentiation pathway of human CD56+CD3- NK cells into CD56+/CD83+/CCR7+/CD25+ cells that display high migratory responsiveness to lymph node (LN)-associated chemokines, high ability to produce interferon-gamma upon exposure to dendritic cell (DC)- or T helper (Th) cell-related signals, and pronounced abilities to promote interleukin (IL)-12p70 production… CONTINUE READING
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