IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

@inproceedings{Chen2011IL17RAIR,
  title={IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke},
  author={Kong Chen and Derek A Pociask and Jeremy P. McAleer and Y. Raymond Chan and John F Alcorn and James L. Kreindler and Matthew R. Keyser and Steven D Shapiro and A. M. Houghton and Jay K Kolls and Mingquan Zheng},
  booktitle={PloS one},
  year={2011}
}
Chronic Obstructive Pulmonary Disease (COPD) is characterized by airspace enlargement and peribronchial lymphoid follicles; however, the immunological mechanisms leading to these pathologic changes remain undefined. Here we show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl hydrocarbon receptor. Smoke exposed IL-17RA(-/-) mice failed to induce CCL2 and MMP12 compared to WT mice. Remarkably, in contrast to WT… CONTINUE READING
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