IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.

@article{Kawaguchi2006IL17FSV,
  title={IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.},
  author={Mio Kawaguchi and Daisuke Takahashi and Nobuyuki Hizawa and Shintaro Suzuki and Satoshi Matsukura and Fumio Kokubu and Yukiko Maeda and Yoshinobu Fukui and Satoshi Konno and S K Huang and Masaharu Nishimura and Mitsuru Adachi},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={117 4},
  pages={795-801}
}
BACKGROUND IL-17F is a recently discovered cytokine that plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma. OBJECTIVE To investigate the role of IL-17F in asthma pathogenesis, we conducted genetic analyses of association of asthma with the… CONTINUE READING
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