IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway.

@article{Kawaguchi2009IL17FinducedIR,
  title={IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway.},
  author={Mio Kawaguchi and Junichi Fujita and Fumio Kokubu and Shengzhu Huang and Tetsuya Homma and Satoshi Matsukura and Mitsuru Adachi and Nobuyuki Hizawa},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={296 5},
  pages={
          L804-10
        }
}
IL-17F is involved in asthma, but its biological function and signaling pathway have not been fully elucidated. IL-11 is clearly expressed in the airway of patients with allergic airway diseases such as asthma and plays an important role in airway remodeling and inflammation. Therefore, we investigated the expression of IL-11 by IL-17F in bronchial epithelial cells. Bronchial epithelial cells were cultured in the presence or absence of IL-17F and/or Th2 cytokines (IL-4 and IL-13) or various… CONTINUE READING
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