IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.

@article{Li2015IL17AII,
  title={IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.},
  author={J Li and Patrizia D'Amelio and Jerid W Robinson and Lindsey D Walker and Chiara Vaccaro and Tao Luo and Abdul Malik Tyagi and Mingcan Yu and Michael A Reott and Francesca Sassi and Ilaria Buondonno and Jonathan K. Adams and Mervyn Neale Weitzmann and Giovanni Carlo Isaia and Roberto Pacifici},
  journal={Cell metabolism},
  year={2015},
  volume={22 5},
  pages={799-810}
}
Primary hyperparathyroidism (PHPT) is a common cause of bone loss that is modeled by continuous PTH (cPTH) infusion. Here we show that the inflammatory cytokine IL-17A is upregulated by PHPT in humans and cPTH in mice. In humans, IL-17A is normalized by parathyroidectomy. In mice, treatment with anti-IL-17A antibody and silencing of IL-17A receptor IL-17RA prevent cPTH-induced osteocytic and osteoblastic RANKL production and bone loss. Mechanistically, cPTH stimulates conventional T cell… CONTINUE READING
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