IL-17 receptor signaling is required to control polymicrobial sepsis

@inproceedings{Freitas2009IL17RS,
  title={IL-17 receptor signaling is required to control polymicrobial sepsis},
  author={Almeida Freitas},
  booktitle={Journal of immunology},
  year={2009}
}
Sepsis is a systemic inflammatory response resulting from the inability of the host to contain the infection locally. Previously, we demonstrated that during severe sepsis there is a marked failure of neutrophil migration to the infection site, which contributes to dissemination of infection, resulting in high mortality. IL-17 plays an important role in neutrophil recruitment. Herein, we investigated the role of IL-17R signaling in polymicrobial sepsis induced by cecal ligation and puncture… CONTINUE READING
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