IL-17 receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

@inproceedings{Herjan2018IL17RA,
  title={IL-17 receptor-associated adaptor Act1 directly stabilizes mRNAs to
mediate IL-17 inflammatory signaling},
  author={Tomasz Herjan and Lingzi Hong and Jodi L. Bubenik and Katarzyna Bulek and Wen Yan Qian and Caini Liu and Xiao Li and Xing C. Chen and H Yang and Suidong Ouyang and Hao Zhou and Junjie Zhao and Kommireddy Vasu and Eric M Cockman and Mark A. Aronica and Kewal Asosingh and Donny D. Licatalosi and Jun Qin and Paul L. Fox and Thomas A Hamilton and Donna M. Driscoll and Xiaoxia Li},
  booktitle={Nature Immunology},
  year={2018}
}
Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-binding element (SBE), in the 3′ untranslated region (UTR) of Cxcl1 mRNA, encoding an inflammatory chemokine. mRNA-bound Act1 directs formation of three compartmentally distinct RNA… CONTINUE READING

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