IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.

@article{Kostka2009IL17PP,
  title={IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.},
  author={Susanna Lopez Kostka and Stephanie Dinges and Klaus G. Griewank and Yoichiro Iwakura and Jonathan C. Vogel and Esther von Stebut},
  journal={Journal of immunology},
  year={2009},
  volume={182 5},
  pages={
          3039-46
        }
}
Resistance to leishmaniasis in C57BL/6 mice depends on Th1/Tc1 cells. BALB/c mice preferentially develop Th2 immunity and succumb to infection. We now assessed the role of IL-17 in cutaneous leishmaniasis. During the course of Leishmania major infection, BALB/c CD4 cells and neutrophils produced increased amounts of IL-17 as compared with cells from C57BL/6 mice. This increase was associated with significantly increased IL-23 release from L. major-infected BALB/c dendritic cells (DC), whereas… CONTINUE READING

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