IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

@inproceedings{Kim2014IL17PI,
  title={IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity},
  author={Hye Young Kim and Hyun Jun Lee and Ya-Jen Chang and Muriel Pichavant and Stephanie A. Shore and Katherine A. Fitzgerald and Yoichiro Iwakura and Helene M Langevin and Kenneth Bolger and John L Faul and Rosemarie H. Dekruyff and Dale T. Umetsu},
  booktitle={Nature Medicine},
  year={2014}
}
Obesity is associated with the development of asthma, which is often difficult to control. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high-fat diet for 12 weeks, which resulted in obesity and the development of airway hyperreactivity (AHR), a cardinal feature of asthma. This AHR was independent of adaptive immunity, as it occurred in obese Rag1−/− mice, which lack B and T cells, and was dependent on interleukin-17A (IL-17A) and the NLRP3… CONTINUE READING
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