IL-17 mediates resistance to anti-VEGF therapy
@article{Maniati2013IL17MR, title={IL-17 mediates resistance to anti-VEGF therapy}, author={Eleni Maniati and Thorsten Hagemann}, journal={Nature Medicine}, year={2013}, volume={19}, pages={1092-1094} }
Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiogenic therapy.
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