IL-17 mediates resistance to anti-VEGF therapy

@article{Maniati2013IL17MR,
  title={IL-17 mediates resistance to anti-VEGF therapy},
  author={Eleni Maniati and Thorsten Hagemann},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={1092-1094}
}
Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiogenic therapy. 
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