IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction.

@article{Shahrara2010IL17mediatedMM,
  title={IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction.},
  author={Shiva Shahrara and Sarah R. Pickens and Arthur M. Mandelin and William J. Karpus and Qi Quan Huang and Jay K Kolls and Richard M. Pope},
  journal={Journal of immunology},
  year={2010},
  volume={184 8},
  pages={
          4479-87
        }
}
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is mediated, in part, by proinflammatory factors produced by RA synovial tissue (ST) fibroblasts and macrophages, resulting in monocyte migration from the blood to the ST. To characterize the potential role of IL-17 in monocyte migration, RA synovial fibroblasts and macrophages were activated with IL-17 and examined for the expression of monocyte chemokines. The two potentially important monocyte chemoattractants identified were… CONTINUE READING

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