IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation

@inproceedings{Lee2013IL17mediatedBE,
  title={IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation},
  author={Seon-Yeong Lee and Seung-Ki Kwok and Hye-Jin Son and J M Ryu and Eun-Kyung Kim and Hye Jwa Oh and Mi-La Cho and Ji Hyeon Ju and Sung Hwan Park and Hang-Rae Kim},
  booktitle={Arthritis research & therapy},
  year={2013}
}
INTRODUCTION Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate whether signal tranducer and activator of transcription 3 (STAT3) is implicated in this process. METHODS Bcl-2 and Bax expression in FLSs was determined using the real-time PCR… CONTINUE READING
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